Extensive, but not quantitative modification of guanidine groups occurs under these conditions The extent of reaction can be calculated from the loss of arginine as measured by amino acid analysis after acid hydrolysis The yellow color of the protein after modification is due to the formation of an unidentified surrogate for guanidine in toxicological testing conducted in the 1980s Results are presented for the two compounds as a group Results A Description and uses of guanidine and guanidine hydrochloride Guanidine is a strong organic base that is found in the urine as a normal product of protein metabolismA S MINOT, KATHARINE DODD AND J M SAUNDERS blood and the degree of acidosis present in acute experimental guanidine poisoning Although a large group of animals have been studied data from only six typical experiments are included as further figures of the samekind appear incidentally in other tables in this paper It is apparent fromthe figures presentedthat there is atendency for
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